If you stay moderate on the power, the Mega slipper can get by. If you move to a motor like the BLX100 motor (a 3660 size motor) and try to run it on 3s, yeah, the Mega slipper will have issues. The BLX100 motor on 2s, I think the slipper will work, mostly.
For pinion, start with the stock pinion, or the 17t. Watch the temps. Depending on the motor, you could try the 26t, but again, watch the temps.
If you want anything other than the 14t, 17t, or 27t, you will need to modify the motor mount, to oval or slot a mounting hole. Not hard, but some people don't like to do that kind of stuff.
For pinion, start with the stock pinion, or the 17t. Watch the temps. Depending on the motor, you could try the 26t, but again, watch the temps.
If you want anything other than the 14t, 17t, or 27t, you will need to modify the motor mount, to oval or slot a mounting hole. Not hard, but some people don't like to do that kind of stuff.