stock tires wear stupid fast on road. I'd say either the Fireteam or backflip MT tires if you're ok with a little more ballooning. For belted I'd say the MethodRC SC or MT tires. Depends on if you do more on road or off.
Yeah they are fantastic in terms off road high-speed performance but very poor agility and handling wise compared to Katars. One of the few wheels I haven't broken yet. Katars I break like everytime I go out.
I drop to around 3s sometimes 4s when running those big wheels. The huge weight increase gets balanced out by the battery pack weight reduction.
I'm running 23/44 gears on a 1650kv can and it's ballistic. So dropping to 3s or 4s still gives amazing speed.