Im planning to run 6s out the box, but I won't beat it so hard that the diff will blow, I think it just depends how much power the driver puts to the throttle/ the car, of course the diffs will blow if you are constantly hitting standing backflips and what not, so I don't think you should be too afraid. I am aware that 6s in general will probably put more stress on the gears
4s would keep you on the safe side, and the diffs wont go out as quickly as on 6s